GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6120141 | 1 | rs6119338 | chr20:31770631 | C20orf70 | chr20:31755960-31769223:+ | -0.39 | -3.52 | 0.000466 | Smooth-surface caries |
| THCA | cis | rs6087771 | 1 | rs6119650 | chr20:30258480 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.88 | 0.000118 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6119652 | chr20:30259445 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.85 | 0.000133 | Subcortical brain region volumes |
| THCA | cis | rs12196860 | 1 | rs61200368 | chr6:55943942 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs6120141 | 1 | rs6120128 | chr20:31752141 | C20orf70 | chr20:31755960-31769223:+ | -0.45 | -3.87 | 0.000124 | Smooth-surface caries |
| THCA | cis | rs6120141 | 1 | rs6120144 | chr20:31770583 | C20orf70 | chr20:31755960-31769223:+ | -0.39 | -3.52 | 0.000466 | Smooth-surface caries |
| THCA | cis | rs6120974 | 1 | rs6120974 | chr20:34126827 | CEP250 | chr20:34042996-34099802:+ | 0.21 | 3.53 | 0.000459 | Triglycerides |
| THCA | cis | rs6120974 | 1 | rs6120974 | chr20:34126827 | CPNE1 | chr20:34213968-34262539:- | -0.71 | -10.98 | 3.69E-25 | Triglycerides |
| THCA | cis | rs6120974 | 1 | rs6120974 | chr20:34126827 | UQCC | chr20:33890383-33999833:- | -0.21 | -4.71 | 3.22E-6 | Triglycerides |
| THCA | cis | rs6087771 | 1 | rs6121038 | chr20:30254773 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.9 | 0.00011 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6121172 | chr20:30296095 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.87 | 0.000124 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6121243 | chr20:30415094 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.91 | 0.000107 | Subcortical brain region volumes |
| THCA | cis | rs7188445 | 1 | rs61221126 | chr16:79733274 | MAF | chr16:79627746-79634622:- | -0.26 | -4.38 | 1.48E-5 | Urate levels |
| THCA | cis | rs6012564 | 1 | rs6122763 | chr20:47797653 | ARFGEF2 | chr20:47538275-47653229:+ | 0.13 | 4.08 | 5.27E-5 | Anger |
| THCA | cis | rs6012564 | 1 | rs6122763 | chr20:47797653 | CSE1L | chr20:47662838-47713484:+ | -0.41 | -10.35 | 8.77E-23 | Anger |